To examine the effect of PKC- inhibitors on LIFR-STAT3 signaling, we cultivated mESCs in the presence of LIF with two kinds of PKC- inhibitors, rotttlerin and GF under hypoxic conditions

By joshbutnerforcongress

To examine the effect of PKC- inhibitors on LIFR-STAT3 signaling, we cultivated mESCs in the presence of LIF with two kinds of PKC- inhibitors, rotttlerin and GF under hypoxic conditions. these results suggest that PKC- inhibitors block the early differentiation of mESCs via destabilization of HIF-1 under hypoxia. = 3). *, < 0.05; **, <…