Additionally, microglia in aged animals show the primed response (Godbout et al
Additionally, microglia in aged animals show the primed response (Godbout et al., 2005) characterized by exaggerated cytokine elaboration to innate immune challenge similar to what is observed in mouse models of chronic neurodegeneration (Combrinck et al., 2002; Cunningham et al., 2005). Such behaviors are the manifestation of pro/anti-inflammatory cytokine action in the brain and are…