Nat Rev Mol Cell Biol 2018;19(9):547C62 doi 10
Nat Rev Mol Cell Biol 2018;19(9):547C62 doi 10.1038/s41580-018-0015-0. with the ataxia telangiectasia mutated (ATM) kinase, in response to DNA harm (11,12). Nevertheless, the complete molecular mechanism where ATM-dependent phosphorylation of PTEN T/S398 regulates its function in DNA harm repair remains generally elusive. Proteins methylation, histone methylation especially, is among the essential post-translational adjustments in regulating…