´╗┐These results are consistent with a recent characterization of CtIP-S326A knock-in mice, which concluded that CDK-dependent phosphorylation of CtIPCBRCA1 interaction domain is dispensable for HR (Reczek et al

By joshbutnerforcongress

´╗┐These results are consistent with a recent characterization of CtIP-S326A knock-in mice, which concluded that CDK-dependent phosphorylation of CtIPCBRCA1 interaction domain is dispensable for HR (Reczek et al., 2013). In addition to S327, the additional CDK-dependent phosphorylation site of CtIP implicated in DSB resection is Thr-847 (Huertas and Jackson, 2009). save of BRCA1-deficiency depend on…