On the other hand, the involvement of one pain assessment tool induces data loss. approach will be conducted. We will demonstrate summary estimates with forest plots in meta-analysis and direct and mixed evidence with a rating of the treatments as the P-score in NMA. The revised Cochrane risk-of-bias tool for randomised trials will be used to assess the methodological quality within individual RCTs. The quality of evidence will be assessed. Ethics and dissemination As this review does not involve individual patients, ethical approval is not required. The results of this systematic review and NMA will be published in a peer-reviewed journal. This review will provide useful information on AIA therapeutic options for clinicians, health practitioners and breast malignancy survivors. PROSPERO registration number CRD42019136967. sensation, electric activation or thermal activation 25,26-Dihydroxyvitamin D3 and so on: acupuncture, auricular acupuncture, electroacupuncture, warm needling, fire needling, pharmacopuncture, catgut embeddingAntidepressive agentsDuloxetine and other antidepressive agentsPhysical therapyPassive physical therapy: transcutaneous electric nerve activation, musculoskeletal manipulations, massage, kinesiology and application of athletic tape (Kinesio tape)Biological productNatural product and herbal medicineBisphosphonates (diphosphonates)Risedronic acid, zoledronic acid and other diphosphonatesExerciseAny types of isometric, mobilising and strengthening exercises: br / aerobic exercise, resistance exercise, aquatic exercise, yoga, Tai Chi, walkingNonopioidsConventional pain or anti-inflammatory medication: br / Non-steroidal anti-inflammatory drugs and acetaminophenOmega-3 fatty acidsA group of unsaturated fatty acids occurring mainly in fish oilsSham acupunctureSham acupuncture designed to inactivate therapeutic effects by manipulating needle insertion location, depth of needle insertion, needle activation and components of patientCpractitioner interactions.Vitamin DHigh dose of vitamin D Open in a separate windows thead Common comparatorType of comparator /thead Inactive controlUsual care, wait-list control, no treatment and any type of placebo Open in a separate windows Sham acupuncture, which is designed to inactivate therapeutic effects, has been included as a control group in acupuncture trials.27 28 However, a growing number of studies have reported that sham acupuncture has comparable effects over no treatment or pharmacological placebo.28C31 Sham acupuncture will be included as a treatment lump to compare its effects with other available treatments in this review. As comparators, studies comparing the effects with inactive control and with active intervention will be both selected. The duration of treatment will Mouse monoclonal to SKP2 not be limited. If no RCT on prespecified treatment classes exists or RCTs on AIA intervention not categorised into 10 classes are found, different treatment categorisation can be considered. The rationale for any post hoc decisions on treatment classes of the network will be reported. Types of outcomes Studies evaluating the switch in patient-reported pain intensity from baseline 25,26-Dihydroxyvitamin D3 (pre-treatment) to post-treatment, which is the main endpoint of this review, measured by using any pain measurement scales will be included in the review. The pain measurement scales will not be specified to exploit all available evidence. Electronic search PubMed, the Cochrane Controlled Register of Trials (CENTRAL), EMBASE, Web of Science and ClinicalTrials. gov will be searched to identify relevant publications in English from inception to November 2019. Also, available recommendations from relevant reviews will be hand-searched to find additional studies. The following search terms will be combined by Boolean 25,26-Dihydroxyvitamin D3 operators: breast neoplasms, aromatase inhibitors, arthralgia joint pain and randomised controlled trial. Search terms relevant to interventions for AIA will not be combined to find all available evidence for current treatments (table 2). The retrieved articles will be managed by EndNote V.X9 (Clarivate Analytics, Philadelphia, Pennsylvania, USA), and the 25,26-Dihydroxyvitamin D3 search results will be recorded in.