Strategies to enhance covalent chimera/inhibitor protein labeling kinetics typically include optimizing electrophile preorganization or enhancing the ligand binding affinity
Strategies to enhance covalent chimera/inhibitor protein labeling kinetics typically include optimizing electrophile preorganization or enhancing the ligand binding affinity. For targeting sugars binding receptors using cARMs, however, these approaches are likely to require extensive medicinal chemistry to yield only modest improvements that are applicable to only a subset of polyclonal antirhamnose antibodies. much less favorableKIassociated…