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By joshbutnerforcongress

E. expression as well as the ensuing hyperactivation of Notch signaling are normal top features of IRF4?/?Vh11 CLL cells. Our research further expose that Notch signaling can be essential for CLL advancement in the IRF4?/?Vh11 mice. Furthermore, we determine E3 ubiquitin ligase Nedd4, which focuses on Notch for degradation, as a primary focus on of…