To further evaluate selectivity, the activity of 34 against the human serine protease dipeptidyl peptidase\4 (DPP4), the aspartate protease beta\secretase 1 (BACE1) and cysteine protease cathepsin?B was measured in an inhibition assay (Figure?6)
To further evaluate selectivity, the activity of 34 against the human serine protease dipeptidyl peptidase\4 (DPP4), the aspartate protease beta\secretase 1 (BACE1) and cysteine protease cathepsin?B was measured in an inhibition assay (Figure?6). 3CLpro over several human proteases. This study presents the first example of metal complexes as Ibuprofen Lysine (NeoProfen) inhibitors for the 3CLpro…