Frequencies of (A) Compact disc4+ and Compact disc8+ T cells (initial -panel), double-negative (DN, Compact disc4-Compact disc8-) and double-positive (DP, Compact disc4+Compact disc8+) T cells (second -panel), Compact disc4+ Tregs (third -panel), and FoxP3-expressing Compact disc8+ T cells (fourth -panel)

By joshbutnerforcongress

Frequencies of (A) Compact disc4+ and Compact disc8+ T cells (initial -panel), double-negative (DN, Compact disc4-Compact disc8-) and double-positive (DP, Compact disc4+Compact disc8+) T cells (second -panel), Compact disc4+ Tregs (third -panel), and FoxP3-expressing Compact disc8+ T cells (fourth -panel). of pDC and LN-resident regular DC (LNR-cDC) activation condition and frequencies, aswell by terminal Compact…

Ann Neurol

By joshbutnerforcongress

Ann Neurol. [1, 2]. Understanding the basis of recovery, as well as the systems that limit growth in the CNS, has been the goal of a century of research. While our understanding remains incomplete, myriad studies have described how injured neurons can be stimulated to grow, overcome physical and chemical barriers, and make functional connections.…

These results are consistent with a recent characterization of CtIP-S326A knock-in mice, which concluded that CDK-dependent phosphorylation of CtIPCBRCA1 interaction domain is dispensable for HR (Reczek et al

By joshbutnerforcongress

These results are consistent with a recent characterization of CtIP-S326A knock-in mice, which concluded that CDK-dependent phosphorylation of CtIPCBRCA1 interaction domain is dispensable for HR (Reczek et al., 2013). In addition to S327, the additional CDK-dependent phosphorylation site of CtIP implicated in DSB resection is Thr-847 (Huertas and Jackson, 2009). save of BRCA1-deficiency depend on…